CUSTOM ITEM: HPLC Column, Diamond Hydride, 4 um, 2.1 mm ID x 150 mm Length, 100 A. Packed in a "metal free" Stainless Steel Column and Frits. Cogent TYPE-C Brand. 1 EA.
Additional Info:
Bio‑Inert Diamond Hydride™ Performance for Low‑Flow Analytical Applications
The 70000‑15D‑2 Bio‑Inert Diamond Hydride™ HPLC Column is a custom‑manufactured analytical column designed for laboratories requiring metal‑free flow paths and precise low‑flow operation. Packed with Cogent TYPE‑C™ silica hydride in bio‑inert, metal‑free stainless‑steel hardware and frits, this column delivers stable retention, rapid equilibration, and extended column lifetime for highly polar and biologically sensitive analytes.
The 2.1 mm ID × 150 mm length format is optimized for laboratories prioritizing reduced solvent consumption, improved sensitivity, and seamless LC‑MS integration where accurate low‑flow control is available.
Why the 2.1 mm Bio‑Inert Configuration Is Selected
This column configuration is selected when analyte protection and sensitivity are critical:
Reduced solvent usage compared to 4.6 mm analytical columns
Improved mass‑sensitive detection and concentration efficiency
Excellent peak shape and retention reproducibility for polar compounds
Bio‑inert hardware minimizes analyte–metal interactions that can distort results
Because of the 2.1 mm internal diameter, this column is best suited for instruments capable of stable, repeatable low‑flow operation.
Diamond Hydride™ Stationary Phase Advantage
Built on Cogent TYPE‑C™ silica hydride technology, the Diamond Hydride™ stationary phase provides advantages not achievable with conventional bonded‑silica HILIC phases:
Very fast equilibration between injections
Highly stable and reproducible retention at elevated organic content
Mixed‑mode interaction mechanisms for difficult polar analytes
Long column lifetime suitable for routine, validated, and regulated workflows
These characteristics support consistent performance over extended analytical sequences.
Ideal Applications
The 70000‑15D‑2 bio‑inert Diamond Hydride column is routinely employed for:
Small, highly polar molecules
Amino acids and organic acids
Polar peptides and metabolites
Proteins and other metal‑sensitive biological analytes
It is especially advantageous where traditional stainless‑steel columns compromise recovery or quantitation.
High‑Resolution HPLC, LC‑MS, and UV Detection
The 150 mm length increases plate count and separation capacity, enabling improved resolution of closely eluting polar compounds. The 2.1 mm ID format supports:
Enhanced sensitivity in LC‑MS workflows
Reduced solvent consumption in routine HPLC analysis
High‑efficiency separations where system dead volume is well controlled
For UV detection, system configuration must support precise low‑flow delivery.
LC‑MS Compatibility and Flow Considerations
This column is fully LC‑MS compatible and commonly used in HILIC‑based LC‑MS methods where controlled low flow is required. Standard analytical HPLC systems must be capable of reliable low‑flow operation to ensure reproducible performance with 2.1 mm ID columns.
Operating Guidelines and System Requirements
Typical flow‑rate range: ~0.2–0.3 mL/min (method‑ and solvent‑dependent)
System compatibility: HPLC or UHPLC systems capable of stable low‑flow delivery
Special requirements: Accurate low‑flow pumping and minimized system dead volume
Flow rates may be further optimized based on pressure limits, resolution goals, and detector configuration.
Custom Item Notice
This product is classified as a Custom Item. Custom items are made to order, non‑returnable, and cannot be canceled once production begins.